有临床证据表面怀孕期间发生的生理和免疫变化与感染和败血症期间疾病恶化的结果有关,但这些关联是如何加剧炎症的发展还没有被研究过。最近,南方医科大学的研究团队在期刊《Immunity》(IF=43.474)上发表题为 “ Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation. ” 的文章,该研究使用抗生素治疗和粪便微生物转移,证明脓毒症易感性是由妊娠诱导的小鼠和人类肠道微生物组的变化驱动的。综合多组学和基因工程细菌揭示,怀孕期间Parabacteroides merdae (P. merdae)(副拟杆菌科(拟杆菌科))数量减少导致芒柄花素(Formononetin,FMN)减少和巨噬细胞死亡增加。从机制上证明,FMN通过抑制hnRNPUL2的核积累和随后与NLRP3启动子的结合来抑制巨噬细胞的核下垂。用FMN治疗或敲除鼠hnRNPUL2可预防脓毒性炎症。P. merdae和FMN的肠道丰度与脓毒症患者的进展呈负相关。该篇文章研究成果揭示了微生物免疫轴在妊娠脓毒症宿主中被破坏,突出了FMN-hnRNPUL2-NLRP3轴在为脓毒症的治疗提供有前景的策略和潜力。
本文中使用了欣博盛Mouse IL-18, IL-1β和 IL-6 ELISA kits检测了血清样本中这些细胞因子的含量。
1.文章题目:Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation.
期 刊:Immunity(影响因子:43.474)
发表时间:14 February 2023
作 者:Chen X, Wu R, Li L, et al.
作者单位:南方医科大学
使用产品:Mouse IL-18, IL-1β and IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36792573/
2.文章题目:Amyloid-β/Tau burden and neuroinflammation dual-targeted nanomedicines synergistically restore memory and recognition of Alzheimer’s disease mice.
期 刊:Nano Today(影响因子:18.962)
发表时间:20 February 2023
作 者:Zhang L, Hou S, Movahedi F, et al.
作者单位:中国科学院过程工程研究所
使用产品:Mouse IL-6, IL-18 and TNF-α ELISA kits
样本类型:脑组织
https://www.sciencedirect.com/science/article/pii/S1748013223000373
3.文章题目:Quantitative Comparison of Gold Nanoparticle Delivery via the Enhanced Permeation and Retention (EPR) Effect and Mesenchymal Stem Cell (MSC)-Based Targeting.
期 刊: ACS nano(影响因子:18.027)
发表时间:1 February 2023
作 者:Xu L, Xu M, Sun X, et al.
作者单位:中国科学院生态环境科学研究中心
使用产品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36717361/
4.文章题目:A hierarchical tumor-targeting strategy for eliciting potent antitumor immunity against triple negative breast cancer.
期 刊:Biomaterials(影响因子:15.304)
发表时间:21 February 2023
作 者:Lin M, Cai Y, Chen G, et al.
作者单位:中山大学
使用产品:Mouse PD-L1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36854221/
5.文章题目:Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells.
期 刊:Acta Pharmaceutica Sinica B(影响因子:14.903)
发表时间:8 February 2023
作 者:Sun X, Xu X, Wang J, et al.
作者单位:吉林大学
使用产品:Mouse IL-15 ELISA kit
https://www.sciencedirect.com/science/article/pii/S2211383523000291
6.文章题目:Immune surveillance of brain metastatic cancer cells is mediated by IFITM1.
期 刊:The EMBO Journal(影响因子:14.012)
发表时间:17 February 2023
作 者:She X, Shen S, Chen G, et al.
作者单位:同济大学
使用产品:Mouse TNF-α ELISA kit
样本类型:脑组织
https://pubmed.ncbi.nlm.nih.gov/36799040/
7.文章题目:Activation of Kruppel-like factor 6 by multi-walled carbon nanotubes in a diameter-dependent manner in THP-1 macrophages in vitro and bronchoalveolar lavage cells in vivo.
期 刊:Environmental Science: Nano(影响因子:9.473)
发表时间:1 February 2023
作 者:Song F, Tang X, Zhao W, et al.
作者单位:南华大学
使用产品:Human MCP-1 ELISA kit
https://pubs.rsc.org/en/content/articlelanding/2023/en/d2en00926a/unauth
8.文章题目:CRISPR/Cas12a coupling with RPA and MNPs for rapid and visualized identification of Methicillin-resistant Staphylococcus aureus.
期 刊:Sensors and Actuators B: Chemical(影响因子:9.221)
发表时间:20 February 2023
作 者:Wu X, Jin D, Ni W, et al.
作者单位:湖北中医药大学
使用产品:TMB底物
https://www.sciencedirect.com/science/article/abs/pii/S0925400523002617
9.文章题目:Immunogenicity Assessment for Swim bladder derived biomaterials.
期 刊:Biomaterials Science(影响因子:7.59)
发表时间:2 February 2023
作 者:Kong Y, Liu J, Jiang H, et al.
作者单位:中国医学科学院和中国协和医科大学
使用产品:Mouse IgG and IgM ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36807688/
10.文章题目:Dietary Antioxidants Constructed Nanodrug for Immunotherapy of Metastatic Tumors.
期 刊:Journal of Materials Chemistry B(影响因子:7.571)
发表时间:27 February 2023
作 者:Wu X, Tan Y, Zhang J, et al.
作者单位:四川大学
使用产品:Mouse TNF-α, IL-6 and IL-10 ELISA kits
样本类型:肿瘤组织匀浆
https://pubs.rsc.org/en/content/articlelanding/2023/tb/d2tb02773a/unauth
11.文章题目:Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy.
期 刊:Drug Delivery(影响因子:6.819)
发表时间:27 February 2023
作 者:Gao Y, Zhang Y, Xia H, et al.
作者单位:沈阳药科大学
使用产品:Mouse TNF-α ELISA kit
https://www.tandfonline.com/doi/full/10.1080/10717544.2023.2183814
12.文章题目:Application of the neuropeptide NPVF to enhance angiogenesis and osteogenesis in bone regeneration.
期 刊:Communications Biology(影响因子:6.548)
发表时间:20 February 2023
作 者:Yu H, Wang Y, Gao J, et al.
作者单位:厦门大学
使用产品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36804475/
13.文章题目:Nanoparticle vaccine based on the envelope protein domain III of Japanese encephalitis virus elicits robust protective immune responses in mice.
期 刊:Nanomedicine(影响因子:6.096)
发表时间:15 February 2023
作 者:Yao M, Ren X, Yin M, et al.
作者单位:华中农业大学
使用产品:Mouse IL-4 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36789970/
14.文章题目:Integrated Proteomics and Metabolomics Analysis to Explore the Amelioration Mechanisms of Rosa roxburghii Tratt Fruit Polyphenols on Lipopolysaccharide-Induced Acute Lung Injury Mice.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:6 February 2023
作 者:Tang L, Zhang S, Zhang M, et al.
作者单位:贵州医科大学
使用产品:Mouse IL-1β, IL-6, IL-10 and TNF-α ELISA kits
样本类型:肺组织
https://pubmed.ncbi.nlm.nih.gov/36745194/
15.文章题目:Anthocyanins from Lycium ruthenicum Murray Ameliorated High-Fructose Diet-Induced Neuroinflammation through the Promotion of the Integrity of the Intestinal Barrier and the Proliferation of Lactobacillus.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:1 February 2023
作 者:Peng Y, Dong W, Chen G, et al.
作者单位:南京农业大学
使用产品:Mouse IL-6, IL-10 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36725206/
16.文章题目:Optimal timing of free total rhubarb anthraquinones on immune regulation in rats with severe acute pancreatitis.
期 刊:Journal of Ethnopharmacology(影响因子:5.195)
发表时间:15 February 2023
作 者:Huang L, Zeng Y, Duan L, et al.
作者单位:西南医科大学
使用产品:Mouse IL-8 ELISA kit
样本类型:小肠组织
https://pubmed.ncbi.nlm.nih.gov/36806482/
17.文章题目:Protective effect and underlying mechanism of muscone on acute cerebral ischemia-reperfusion injury in rats.
期 刊:Journal of Ethnopharmacology(影响因子:5.195)
发表时间:24 February 2023
作 者:Zhang P, You S, Ding X, et al.
作者单位:上海中医药大学
使用产品:Human VEGF, MMP-9 and bFGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36841376/
18.文章题目:VX-765 ameliorates CKD VSMC calcification by regulating STAT3 activation.
期 刊:European Journal of Pharmacology(影响因子:5.195)
发表时间:28 February 2023
作 者:Duan Y, Peng Z, Zhong S, et al.
作者单位:南华大学
使用产品:Rat IL-1β, IL-18, and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36858340/
19.文章题目:Osteoprotegerin deficiency aggravates methionine–choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
期 刊:Scientific Reports(影响因子:4.996)
发表时间:23 February 2023
作 者:Wu S, Wu Y, Lin L, et al.
作者单位:重庆大学
使用产品:Histostain-Plus IHC Kit, Mouse Primary
https://pubmed.ncbi.nlm.nih.gov/36823220/
20.文章题目:Production and Anti-Inflammatory Performance of PVA Hydrogels Loaded with Curcumin Encapsulated in Octenyl Succinic Anhydride Modified Schizophyllan as Wound Dressings.
期 刊:Molecules(影响因子:4.927)
发表时间:1 February 2023
作 者:Tu L, Fan Y, Deng Y, et al.
作者单位:广西大学
使用产品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36770985/
21.文章题目:Evaluation of biomarkers from peritoneal fluid as predictors of severity for abdominal sepsis patients following emergency laparotomy.
期 刊:Journal of Inflammation Research(影响因子:4.631)
发表时间:23 February 2023
作 者:Zhao J, Zhang T, Deng Z, et al.
作者单位:天津医科大学
使用产品:Human IL-3 ELISA kit
https://www.tandfonline.com/doi/full/10.2147/JIR.S401428
22.文章题目:Decreased Peli1 expression attenuates osteoarthritis by protecting chondrocytes and inhibiting M1-polarization of macrophages.
期 刊:Bone & Joint Research(影响因子:4.41)
发表时间:1 February 2023
作 者:Mo H, Wang Z, He Z, et al.
作者单位:华中科技大学
使用产品:Mouse IL-1β, IL-6, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36718653/
23.文章题目:Dual-responsive antibiotic and baicalein co-delivery nanoparticles with enhanced synergistic antibacterial activity.
期 刊:Journal of Biomaterials Science Polymer Edition(影响因子:3.682)
发表时间:17 February 2023
作 者:Liu Y, Qian J, Zhao X, et al..
作者单位:贵州医科大学
使用产品:Mouse TNF-α ELISA kit
https://www.tandfonline.com/doi/abs/10.1080/09205063.2023.2182575
24.文章题目:Isochlorogenic Acid C Restrains Erk/JNK/NF-κB Signaling to Alleviate Inflammatory Response and Promote Cell Apoptosis.
期 刊:Journal of Food Biochemistry(影响因子:3.654)
发表时间:20 February 2023
作 者:Liu Y, Liang J, Ding Q, et al.
作者单位:贵州中医药大学
使用产品:Rat IL-1β, IL-6, TNF-α, IFN-γ,CXCL1, IL-17/IL-17A ELISA kits, Human IL-1β , IL-18,MIP-1α, MCP-1 ELISA kits
https://www.hindawi.com/journals/jfbc/2023/5547108/
25.文章题目:Resveratrol Inhibits Activation of Microglia after Stroke through Triggering Translocation of Smo to Primary Cilia.
期 刊:Journal of Personalized Medicine(影响因子:3.508)
发表时间:1 February 2023
作 者:Liao H, Huang J, Liu J, et al.
作者单位:重庆医科大学
使用产品:Mouse TNF-α, IL-1β and IL-10 ELISA kits
样本类型:脑组织
https://pubmed.ncbi.nlm.nih.gov/36836502/
26.文章题目:Anti-TNFR2 enhanced the antitumor activity of a new HMGN1/3M-052 stimulated dendritic cell vaccine in a mouse model of colon cancer.
期 刊:Biochemical and Biophysical Research Communications(影响因子:3.322)
发表时间:16 February 2023
作 者:Zhu L, Zhang X, Chen X, et al.
作者单位:贵州大学医学院
使用产品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36868074/
27.文章题目:Filamin A is overexpressed in non-alcoholic steatohepatitis and contributes to the progression of inflammation and fibrosis.
期 刊:Biochemical and Biophysical Research Communications(影响因子:3.322)
发表时间:22 February 2023
作 者:Lu Y, Wang M, Zhao M, et al.
作者单位:四川大学
使用产品:Human TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36863213/
28.文章题目:Irisin Attenuates Fine Particulate Matter Induced Acute Lung Injury by Regulating Nod2/NF-κB Signaling Pathway.
期 刊:Immunobiology(影响因子:3.152)
发表时间:24 February 2023
作 者:Jiao R, Han Z, Ma J, et al.
作者单位:河北医科大学
使用产品:Mouse TNF-α, IL-1β and IL-18 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0171298523000268
29.文章题目:A multi-target protective effect of Danggui-Shaoyao-San on the vascular endothelium of atherosclerotic mice.
期 刊:BMC Complementary Medicine and Therapies(影响因子:2.838)
发表时间:20 February 2023
作 者:Sun Y, Gao Y, Zhou L, et al.
作者单位:北京中医药大学
使用产品:Mouse IL-8 ELISA kit
样本类型:主动脉组织
https://pubmed.ncbi.nlm.nih.gov/36803348/
30.文章题目:Roles of PADI4 in the expression of cytokines involved in inflammation and adhesion in differentiated NB4 cells treated with ATRA.
期 刊:Experimental and Therapeutic Medicine(影响因子:2.751)
发表时间:1 February 2023
作 者:Sun X, Mu X, Li F, et al.
作者单位:山东大学
使用产品:Human TNF-α, IL-1β and IL-8 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36815967/
31.文章题目:Anti‐Inflammatory Activities of Monoterpene and Sesquiterpene Glycosides from the Aqueous Extract of Artemisia annua L.
期 刊:Chemistry & Biodiversity(影响因子:2.745)
发表时间:5 February 2023
作 者:Wu Q G, Huang L Y, Fan M H, et al.
作者单位:上海中医药大学
使用产品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36740572/
32.文章题目:Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway.
期 刊:Molecular Biology Reports(影响因子:2.742)
发表时间:1 February 2023
作 者:Liao H, Huang J, Liu J, et al.
作者单位:重庆医科大学
使用产品:Mouse TNF-α, IL-1β and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36725745/
33.文章题目:Sitagliptin Attenuates Porphyromonas Gingivalis Virulence and Inflammatory Response in Macrophage on Titanium.
期 刊:Archives of Oral Biology(影响因子:2.64)
发表时间:23 February 2023
作 者:Tang W, Du M, Zhang S, et al.
作者单位:武汉大学口腔医院
使用产品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36871330/
34.文章题目:Effect of lipoxin A 4 methyl ester from arachidonic acid on JAK2/STAT3 pathway after cerebral ischemia-reperfusion injury.
期 刊:Food Science and Technology(影响因子:2.602)
发表时间:1 February 2023
作 者:YE X, WU Y, CHEN Q, et al.
作者单位:湖北文理学院附属医院
使用产品:Mouse IL-6 ELISA kit
https://www.scielo.br/j/cta/a/F6mqLNJSNCbFnHRnxxBW8tw/abstract/?lang=en
35.文章题目:The effects of alginate lyase treatment on structural characteristics and anti‐photoaging activity of alginate from Sargassum fusiforme.
期 刊:Food Frontiers(影响因子:2.05)
发表时间:24 February 2023
作 者:Chang S, Hu J, Zhu B, et al.
作者单位:华南理工大学
使用产品:Human MMP-1 and MMP-9 ELISA kits
https://onlinelibrary.wiley.com/doi/full/10.1002/fft2.218
36.文章题目:Probiotics-loaded carrageenan microspheres for inflammatory bowel disease treatment.
期 刊:Materials Research Express(影响因子:2.025)
发表时间:17 February 2023
作 者:Yang X, Li C, Wu Q, et al.
作者单位:九江市第一人民医院
使用产品:Mouse IL-10, IL-6, IL-β, TNF-α ELISA kits
https://iopscience.iop.org/article/10.1088/2053-1591/acbae6/meta
37.文章题目:The inhibitory function of GDF11/BMP11 in liver cancer by inducing apoptosis and ROS–JNK pathway.
期 刊:Oncologie(影响因子:0.9)
发表时间:15 February 2023
作 者:Zhang Y, Wang C, Li J, et al.
作者单位:三峡医学院附属人民医院
使用产品:Annexin V-FITC/PI apoptosis assay kit
https://www.degruyter.com/document/doi/10.1515/oncologie-2023-0001/html