2025年1月,苏州大学程亮教授团队在Advanced Materials(IF=27.4)上发表题为“Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.(锰原电池调控肿瘤代谢以增强cGAS-STING激活,实现双向协同氢免疫疗法)”的研究。
cGAS-STING通路在触发抗肿瘤免疫以及将“冷”肿瘤转变为“热”肿瘤的过程中起到关键作用。前期大量研究结果表明,Mn2+可以增强cGAS-STING通路的激活,从而提高肿瘤治疗效果。然而,肿瘤复杂的代谢微环境对cGAS-STING通路的激活有潜在影响。据报道,肿瘤代谢过程,尤其是糖酵解过程,能够负向调控cGAS-STING通路的激活。因此,开发高效策略以实现锰基STING激动剂有效递送的同时,调控肿瘤细胞糖酵解进一步增强cGAS-STING通路激活具有重要意义。近日,苏州大学程亮教授团队开发了一种锰原电池(Mn galvanic cells,MnG)策略,通过调节肿瘤代谢以进一步增强cGAS-STING通路的激活,进而实现高效双向协同氢免疫疗法,显著提升肿瘤治疗疗效的目的。该研究不仅强调了通过有效构建金属原电池策略诱导生物学效应以增强免疫治疗的重要性,还证明了该策略在调节肿瘤糖代谢增强cGAS-STING激活以实现协同治疗的可行性,为合理设计生物活性材料及其在肿瘤免疫治疗中的应用提供了进一步的发展机会。
该项研究中,使用了欣博盛生物(NeoBioscience Technology Co, Ltd)的Mouse TNF-α ELISA Kit,用于检测肿瘤组织中相关指标的含量。
货号 | 产品名称 | 灵敏度 | 检测范围 |
QuantiCyto® Mouse TNF-α ELISA kit (小鼠肿瘤坏死因子-α) | 15.6pg/ml | 31.25-2000pg/ml |
欣博盛生物作为供应商,为该研究提供了高质量ELISA试剂盒。这不仅帮助了研究团队在实验中取得可靠的数据,也彰显了我们致力于支持生物医学领域科研进展的承诺。
2025年1月文献引用
1. Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.(ADVANCED MATERIALS, IF=27.4)
发表时间:2025/1/7
作者单位:苏州大学
引用产品:Mouse TNF-α ELISA kit
样本类型:组织样本
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202414929
2. Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer.(Nature Communications, IF=14.7)
发表时间:2025/1/15
作者单位:上海药物研究所
引用产品:Mouse M-CSF, IL-12p70, IL-10, IL-2, TNF-α and IFN-γ ELISA kits
样本类型:引流淋巴结(DLN),血清
https://www.nature.com/articles/s41467-025-55904-z
3. Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach.(Nature Communications, IF=14.7)
发表时间:2025/1/18
作者单位:中山大学附属第一医院
引用产品:Human CXCL10 ELISA Kit
样本类型:AGS, MKN28细胞培养上清
https://www.nature.com/articles/s41467-025-56173-6
4. Butterfly-shaped dendrimers with photosensitizer recruitment function for enhanced light-controlled precise cascaded ROS and NO release in multimodal diabetic foot ulcers infections treatment.(CHEMICAL ENGINEERING JOURNAL, IF=13.3)
发表时间:2025/1/7
作者单位:福建医科大学
引用产品:Mouse TNF-α ELISA kit
样本类型:RAW264.7细胞培养上清
https://www.sciencedirect.com/science/article/pii/S1385894725001792
5. Tunable ion-release biodegradable nanoparticles enhanced pyroptosis for tumor immunotherapy.(BIOMATERIALS, IF=12.8)
发表时间:2025/1/15
作者单位:福建医科大学
引用产品:Mouse IL-1β, IL-6, IL-10, IL-12p70, TNF-α and IFN-γ ELISA kits
样本类型:树突状细胞(DCs)上清,血清
https://www.sciencedirect.com/science/article/pii/S0142961225000304
6. YAP1 mediates the dimensional and chemical coordination of immunoregulation and therapy in extensively passaged mesenchymal stem cells.(Theranostics, IF=12.4)
发表时间:2025/1/6
作者单位:西安交通大学
引用产品:Mouse TNF-α, IL-6 and TGF-β1 ELISA kits
样本类型:血清,间充质干细胞(MSCs)上清,T细胞上清
https://pmc.ncbi.nlm.nih.gov/articles/PMC11780522/
7. Large-scale multicenter study reveals anticitrullinated SR-A peptide antibody as a biomarker and exacerbator for rheumatoid arthritis.(Science Advances, IF=11.7)
发表时间:2025/1/3
作者单位:北京大学人民医院
引用产品:Human IL-6 and IL-8 ELISA kits
样本类型:软骨类器官细胞裂解液
https://www.science.org/doi/abs/10.1126/sciadv.adr8078
8. Ice-pop making inspired photothermal ultra-swelling microneedles to facilitate loading and intradermal vaccination of tumor antigen.(JOURNAL OF CONTROLLED RELEASE, IF=10.5)
发表时间:2025/1/8
作者单位:中国科学院杭州医学研究所
引用产品:Mouse IFN-γ, TNF-α and IL-6 ELISA kits
样本类型:血清,脾脏组织
https://www.sciencedirect.com/science/article/pii/S0168365924009313
9. Multiple synergistic anti-aging effects of vascular cell adhesion molecule 1 functionalized nanoplatform to improve age-related neurodegenerative diseases.(JOURNAL OF CONTROLLED RELEASE, IF=10.5)
发表时间:2025/1/15
作者单位:重庆大学
引用产品:Mouse IL-6 and TNF-α ELISA kits
样本类型:脑组织
https://www.sciencedirect.com/science/article/pii/S0168365925000239
10. Trojan Horse-Like Biohybrid Nanozyme for Ameliorating Liver Ischemia-Reperfusion Injury.(Advanced Healthcare Materials, IF=10)
发表时间:2025/1/19
作者单位:陆军军医大学第二附属医院
引用产品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
样本类型:血清,肝组织
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202404458
11. A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA.(JOURNAL OF BIOMEDICAL SCIENCE, IF=9)
发表时间:2025/1/8
作者单位:中国医学科学院基础医学研究所
引用产品:HRP-conjugated secondary antibody
样本类型:人脂肪源性间充质干细胞上清
https://link.springer.com/article/10.1186/s12929-024-01098-3
12. The role of phospholipid transfer protein in sepsis-associated acute kidney injury.(CRITICAL CARE, IF=8.8)
发表时间:2025/1/20
作者单位:扬州大学附属苏北人民医院
引用产品:Mouse TNF-α and IL-6 ELISA kits
样本类型:血浆
https://link.springer.com/article/10.1186/s13054-025-05253-6
13. Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment.(Materials Today Bio, IF=8.7)
发表时间:2025/1/1
作者单位:安徽中医药大学
引用产品:Human TGF-β1 ELISA kit
样本类型:肿瘤组织
https://www.sciencedirect.com/science/article/pii/S2590006424005027
14. Extraction, isolation, identification and bioactivity of anthraquinones from Aspergillus cristatus derived from Fuzhaun brick tea.(FOOD CHEMISTRY, IF=8.5)
发表时间:2025/1/30
作者单位:南京农业大学
引用产品:Mouse TNF-α and IL-6 ELISA kits
样本类型:RAW264.7细胞培养上清
https://www.sciencedirect.com/science/article/pii/S0308814625003541
15. SHED-Derived Exosomes Ameliorate Sjögren’s Syndrome-Induced Hyposalivation by Suppressing Th1 Cell Response via the miR-29a-3p/T-bet Axis.(ACS Applied Materials & Interfaces, IF=8.3)
发表时间:2025/1/13
作者单位:北京大学口腔医学院
引用产品:Mouse IFN-γ and TNF-α ELISA kits
样本类型:淋巴细胞上清和SMG匀浆
https://pubs.acs.org/doi/abs/10.1021/acsami.4c16595
16. Transcriptomic modifications across the genome and potential hazards of pulmonary fibrosis caused by metal-organic frameworks.(SCIENCE OF THE TOTAL ENVIRONMENT, IF=8.2)
发表时间:2025/1/23
作者单位:上海理工大学
引用产品:Human IL-1β, TGF-β1 and TNF-α ELISA kits
样本类型:人支气管上皮细胞上清
https://www.sciencedirect.com/science/article/pii/S004896972500138X
17. Development of high-strength, 3D-printable, and biocompatible gelatin/κ-carrageenan dual-network hydrogels for wound healing.(INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, IF=7.7)
发表时间:2025/1/27
作者单位:广州医科大学附属清远医院
引用产品:Annexin V-FITC/PI apoptosis assay kit
https://www.sciencedirect.com/science/article/pii/S0141813025009298
18. Peonidin-3-O-(3,6-O-dimalonyl-β-D-glucoside), a polyacylated anthocyanin isolated from the black corncobs, alleviates colitis by modulating gut microbiota in DSS-induced mice.(FOOD RESEARCH INTERNATIONAL, IF=7)
发表时间:2025/1/6
作者单位:安徽科技大学
引用产品:Mouse TNF-α, IL-6, IL-1β, IFN-γ and MCP-1 ELISA kits
样本类型:血清
https://www.sciencedirect.com/science/article/pii/S0963996925000249
19. Dietary Linolenic Acid Enhances IgE Binding to Bovine α-Lactalbumin/β-Lactoglobulin and Promotes KU812 Basophil Degranulation via Upregulation of the Lyn/Syk Pathway.(JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, IF=5.7)
发表时间:2025/1/7
作者单位:南昌大学
引用产品:Human IL-6 ELISA Kit, TMB (standard sensitivity)
样本类型:血清
https://pubs.acs.org/doi/abs/10.1021/acs.jafc.4c10482
20. Titanium nanotubes modulate immunophenotyping and cytokine secretion of T cells via IL-17A: a bioinformatic analysis and experimental validation.(Frontiers in Immunology, IF=5.7)
发表时间:2025/1/7
作者单位:福建医科大学第一附属医院
引用产品:Rat IL-17/IL-17A ELISA kit
样本类型:KU812细胞上清
https://pmc.ncbi.nlm.nih.gov/articles/PMC11747796/
21. Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD.(Frontiers in Immunology, IF=5.7)
发表时间:2025/1/7
作者单位:中国中医科学院广安门医院
引用产品:Mouse TNF-α , IL-1β and IL-6 ELISA kits
样本类型:血清
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1445924/full
22. Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis.(Frontiers in Immunology, IF=5.7)
发表时间:2025/1/7
作者单位:苏州大学第一附属医院
引用产品:Mouse IL-4, IL-5, IL-13 and IgE ELISA kits
样本类型:鼻腔灌洗液,血清
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1460104/full
23. Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway.(Frontiers in Immunology, IF=5.7)
发表时间:2025/1/14
作者单位:江苏省人民医院
引用产品:Rat IL-18 and IL-1β ELISA kits
样本类型:大鼠主动脉内皮细胞上清
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1532021/full
24. Gut microbe-derived betulinic acid alleviates sepsis-induced acute liver injury by inhibiting macrophage NLRP3 inflammasome in mice.(mBio, IF=5.1)
发表时间:2025/1/31
作者单位:广东省医学科学院
引用产品:Mouse IL-1β, TNF-α and IL-6 ELISA kits
样本类型:血清
https://journals.asm.org/doi/abs/10.1128/mbio.03020-24
25. Runx2-NLRP3 Axis Orchestrates Matrix Stiffness-evoked Vascular Smooth Muscle Cell Inflammation.(AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, IF=5)
发表时间:2025/1/6
作者单位:北京大学基础医学院
引用产品:Mouse MCP-1 and IL-6 ELISA kits
样本类型:血清
https://journals.physiology.org/doi/abs/10.1152/ajpcell.00448.2024
26. Cucurbitacin IIb mitigates concanavalin A-induced acute liver injury by suppressing M1 macrophage polarization.(INTERNATIONAL IMMUNOPHARMACOLOGY, IF=4.8)
发表时间:2025/1/3
作者单位:济宁医学院免疫与分子医学研究所
引用产品:Mouse IL-1β ELISA kit
样本类型:血清、骨髓源性巨噬细胞上清
https://www.sciencedirect.com/science/article/pii/S156757692402486X
27. Jiawei Ermiao Granules (JWEMGs) clear persistent HR-HPV infection though improving vaginal microecology.(JOURNAL OF ETHNOPHARMACOLOGY, IF=4.8)
发表时间:2025/1/9
作者单位:南京中医药大学第一临床医学院
引用产品:Human IL-6, IL-8 and TNF-α ELISA kits
样本类型:阴道灌洗液
https://www.sciencedirect.com/science/article/pii/S037887412500025X
28. Effects of Lutjanus erythropterus Protein on Depression-like Behavior and Gut Microbiota in Stressed Juvenile Mice.(Foods, IF=4.7)
发表时间:2025/1/20
作者单位:广东海洋大学
引用产品:Mouse TNF-α, IL-β, IL-2 and IL-6 ELISA kits
样本类型:血清
https://www.mdpi.com/2304-8158/14/2/330
29. Dual efficacy of tocilizumab in managing PD-1 inhibitors-induced myocardial inflammatory injury and suppressing tumor growth with PD-1 inhibitors: a preclinical study.(CANCER IMMUNOLOGY IMMUNOTHERAPY, IF=4.6)
发表时间:2025/1/3
作者单位:南昌大学
引用产品:Mouse IL-6 and TNF-α ELISA kits
样本类型:血清
https://link.springer.com/article/10.1007/s00262-024-03899-9
30. STC1 encapsulated in small extracellular vesicles from laryngeal squamous cell carcinoma cells induces CD8+ T cell dysfunction by reprogramming tumor-associated macrophages into M2-like macrophages.(CANCER IMMUNOLOGY IMMUNOTHERAPY, IF=4.6)
发表时间:2025/1/3
作者单位:哈尔滨医科大学
引用产品:Human PD-L1/B7-H1 ELISA kit
样本类型:THP-1细胞上清
https://link.springer.com/article/10.1007/s00262-024-03915-y
31. The injury effect of osteopontin in sepsis-associated lung injury.(Journal of Inflammation-London, IF=4.4)
发表时间:2025/1/24
作者单位:重庆医科大学附属儿童医院
引用产品:Human IL-6 ELISA kit; Mouse TNF-α, IL-1β and IL-6 ELISA kits
样本类型:血清
https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-025-00430-4
32. Portulaca oleracea L. (purslane) extract ameliorates intestinal inflammation in diet-induced obese mice by inhibiting the TLR4/NF-κB signaling pathway.(Frontiers in Pharmacology, IF=4.4)
发表时间:2025/1/7
作者单位:澳门大学
引用产品:Mouse IL-6 and TNF-α ELISA kits
样本类型:肠组织
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1474989/full
33. Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function.(Frontiers in Microbiology, IF=4)
发表时间:2025/1/22
作者单位:昆明医科大学
引用产品:Mouse IL-4, IL-17/IL-17A, TGF-β1 and IFN-γ ELISA kits
样本类型:结肠组织
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1496280/full
34. ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation.(Scientific Reports, IF=3.8)
发表时间:2025/1/6
作者单位:重庆医科大学第一附属医院
引用产品:Rat IL-10, TNF-α and IL-1β ELISA kits
样本类型:血清,库普弗细胞(KCs)上清、肝细胞(HCs)上清
https://www.nature.com/articles/s41598-024-81832-x
35. Isoliquiritigenin Protects Against Diabetic Nephropathy in db/db Mice by Inhibiting Advanced Glycation End Product–Receptor for Advanced Glycation End Product Axis.(DRUG DEVELOPMENT RESEARCH, IF=3.5)
发表时间:2025/1/27
作者单位:绿色制药协同创新中心
引用产品:Mouse TNF-α, IL-8 and MCP-1 ELISA kits
样本类型:血清
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/ddr.70051
36. Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway.(Heliyon, IF=3.4)
发表时间:2025/1/22
作者单位:深圳市宝安区人民医院
引用产品:Annexin V-FITC/PI Apoptosis Detection Kit
https://www.cell.com/heliyon/fulltext/S2405-8440(25)00539-0
37. Acupoint catgut embedding alleviates experimental autoimmune encephalomyelitis by modulating neuroinflammation and potentially inhibiting glia activation through JNK and ERK pathways.(Frontiers in Neuroscience, IF=3.2)
发表时间:2025/1/9
作者单位:中山大学附属第三医院
引用产品:Mouse IL-1β and IL-6 ELISA kits
样本类型:血清
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1520092/full
38. Clinical characteristics of bullous pemphigoid patients of different ages and the possible mechanism.(JOURNAL OF DERMATOLOGY, IF=2.9)
发表时间:2025/1/17
作者单位:中国医学科学院北京协和医学院
引用产品:Human IL-1α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-13, TNF-α, IFN-γ and TGF-β1 ELISA kits
样本类型:大鼠嗜碱性细胞白血病细胞(RBL-2H3)上清
https://onlinelibrary.wiley.com/doi/abs/10.1111/1346-8138.17616
39. Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4+ T Cells.(CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, IF=2.4)
发表时间:2025/1/5
作者单位:江西省人民医院
引用产品:Human IFN-γ, IL-10, IL-17, IFN-γ, IL-10, IL-17/IL-17A ELISA kits
样本类型:血清
https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.70018
40. Constructing the Well Regenerated Decellularized Adipose Tissue Using External Volume Expansion Device.(AESTHETIC PLASTIC SURGERY, IF=2)
发表时间:2025/1/13
作者单位:空军军医大学西京医院
引用产品:Rat TNF-α and CCL2/JE/MCP-1 ELISA kits
样本类型:脂肪组织
https://link.springer.com/article/10.1007/s00266-024-04604-y
41. Tripterygium wilfordii attenuates IgE-mediated type I allergy by regulating Th1/Th2 balance.(Advances in Traditional Medicine, IF=1.8)
发表时间:2025/1/9
作者单位:河北大学
引用产品:Rat TNF-α, IFN-γ and IL-4 ELISA kits
样本类型:血清
https://link.springer.com/article/10.1007/s13596-024-00815-5
42. Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway.(JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, IF=1.3)
发表时间:2025/1/1
作者单位:中国医学科学院北京协和医学院
引用产品:Mouse TNF-α ELISA kit
样本类型:小鼠小胶质细胞(BV2)上清
https://www.tandfonline.com/doi/abs/10.1080/10286020.2024.2435981